Cattle Drive Casserole Recipe
Introduction
Cattle Drive Casserole is a hearty, flavorful dish that combines seasoned ground beef with a cheesy, creamy topping over a biscuit crust. Perfect for family dinners, it’s easy to prepare and delivers comforting southwestern flavors.

Ingredients
- 1.5 pounds Lean Ground Beef
- 1 Red Bell Pepper, seeded and chopped
- 1 Yellow Onion, chopped
- 1 ounce Taco Seasoning Mix
- 2 ½ cups Biscuit Mix (like Bisquick)
- 1 cup Water
- Cooking Spray (like Pam)
- ½ cup Sour Cream
- ½ cup Mayonnaise
- 4 ounces Diced Green Chiles, drained
- 1 ½ cups Cheddar Cheese Fiesta Blend, shredded, divided
- 1 teaspoon Garlic Powder
- ½ cup Mild Salsa
Instructions
- Step 1: Preheat the oven to 350℉.
- Step 2: In a large skillet over medium-high heat, cook the ground beef, breaking it apart with a spoon, until no longer pink. Stir occasionally and drain excess fat. While the beef cooks, prepare the biscuit dough.
- Step 3: In a medium mixing bowl, combine the biscuit mix and water. Stir until well blended, using your hands if desired. Spray a 9 x 13-inch casserole dish with cooking spray, press the dough evenly into the dish, and bake for 5-8 minutes until set and lightly golden. Set aside but keep the oven on.
- Step 4: Add the chopped onion and red bell pepper to the skillet with the ground beef. Cook for about 4 minutes until tender. Stir in the taco seasoning, then remove from heat.
- Step 5: Spread the beef and vegetable mixture evenly over the baked biscuit crust.
- Step 6: In a medium bowl, mix sour cream, mayonnaise, drained green chiles, ¾ cup shredded cheese, and garlic powder until smooth. Spread this mixture carefully over the beef layer.
- Step 7: Spoon small dollops of salsa over the sour cream layer without spreading. Sprinkle the remaining shredded cheese evenly on top.
- Step 8: Bake the casserole uncovered for 30 minutes, or until hot and bubbly. Serve warm.
Tips & Variations
- For extra spice, use a medium or hot salsa instead of mild.
- Swap out the green chiles for jalapeños if you prefer more heat.
- Use a gluten-free biscuit mix to make the casserole gluten-free.
- Add corn or black beans to the beef mixture for added texture and flavor.
Storage
Store leftover casserole in an airtight container in the refrigerator for up to 3 days. Reheat individual portions in the microwave or oven until warmed through. This dish can also be frozen for up to 2 months; thaw overnight in the fridge before reheating.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use fresh tortillas instead of biscuit mix?
While the biscuit crust provides a unique texture, you can substitute with a layer of corn or flour tortillas for a different style casserole. Adjust baking time accordingly.
Is this casserole suitable for freezing?
Yes, the casserole freezes well. Cover tightly with foil or plastic wrap and freeze for up to 2 months. Thaw in the refrigerator before baking or reheating.
PrintCattle Drive Casserole Recipe
Cattle Drive Casserole is a hearty and comforting layered casserole featuring seasoned ground beef, a biscuit crust, and a creamy cheese topping with a southwestern flair. This one-dish meal combines simple ingredients with easy preparation, perfect for a family dinner or potluck.
- Prep Time: 15 minutes
- Cook Time: 40 minutes
- Total Time: 55 minutes
- Yield: 8 servings 1x
- Category: Main Dish
- Method: Baking
- Cuisine: American
Ingredients
Meat and Vegetables
- 1.5 pounds Lean Ground Beef
- 1 Red Bell Pepper, seeded and chopped
- 1 Yellow Onion, chopped
- 1 ounce Taco Seasoning Mix
Biscuit Crust
- 2 ½ cups Biscuit Mix (such as Bisquick)
- 1 cup Water
- Cooking Spray (like Pam)
Sour Cream Layer
- ½ cup Sour Cream
- ½ cup Mayonnaise
- 4 ounces Diced Green Chiles, drained
- 1 ½ cups Cheddar Cheese, Fiesta Blend, shredded, divided
- 1 teaspoon Garlic Powder
Topping
- ½ cup Salsa, mild
Instructions
- Preheat the Oven: Preheat your oven to 350°F (175°C) to ensure it is ready to bake the biscuit crust and later the assembled casserole.
- Cook the Ground Beef: Heat a large skillet over medium-high heat. Add the ground beef and break it up with a spoon or spatula. Cook until completely browned and no pink remains, stirring occasionally. Drain off any excess fat to keep the casserole from becoming greasy.
- Prepare the Biscuit Dough: While the beef cooks, combine the biscuit mix and water in a medium mixing bowl. Stir thoroughly until you get a consistent dough; using your hands for mixing helps achieve even texture. Spray a 9 x 13-inch casserole dish with cooking spray, then press the dough evenly into the dish, spreading it to cover the bottom and edges. Bake this crust in the preheated oven for 5-8 minutes until it is set and lightly golden. Remove from oven but keep the oven on.
- Cook the Vegetables: To the cooked ground beef in the skillet, add the chopped onion and red bell pepper. Sauté for approximately 4 minutes until softened. Stir in the taco seasoning mix until well combined, then remove the skillet from heat.
- Assemble the Layers: Evenly spread the seasoned ground beef and vegetable mixture over the partially baked biscuit crust in the casserole dish.
- Prepare the Sour Cream Layer: In another medium bowl, combine sour cream, mayonnaise, drained diced green chiles, ¾ cup of the shredded cheddar cheese, and garlic powder. Mix thoroughly until smooth. Carefully spread this creamy mixture over the beef layer in the casserole dish.
- Add Salsa and Cheese: Place small spoonfuls of mild salsa over the sour cream layer without spreading them out. Sprinkle the remaining ¾ cup (remaining cheese) evenly over the top to finish the layers.
- Bake the Casserole: Return the assembled casserole to the oven, uncovered. Bake for 30 minutes or until the casserole is hot and bubbly and the cheese topping is melted and slightly browned.
Notes
- You can substitute the taco seasoning mix with homemade seasoning if preferred for a lower sodium option.
- Using lean ground beef helps reduce fat content and prevents excess grease in the casserole.
- For extra heat, use a spicier salsa or add jalapeños to the green chile layer.
- Make sure to drain excess fat from the beef to keep the casserole from becoming greasy.
- The biscuit crust can be prepared ahead of time and partially baked before assembling.
Keywords: cattle drive casserole, ground beef casserole, biscuit crust casserole, southwestern casserole, easy family dinner, layered casserole

